Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR). The first studies about role of ghrelin were focused on its orexigenic ability, but despite indisputable pharmacological data, the evidence for a physiological role for ghrelin in the control of appetite is much less clear....

Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion

Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set diabetes. The cellular mechanisms behind the development of diabetes by statins are elusive. Here we have treated mice on normal diet (ND) and high fat diet (HFD) with rosuvastatin. Under ND rosuvastatin lowered blood glucose through impro...

The Role of Skeletal Muscle in Glucose Transport, Glucose Homeostasis, and Insulin Resistance: Implications

Role of ghrelin in glucose homeostasis and diabetes Review

171 ISSN 1758-1907 10.2217/DMT.12.88 © 2013 Future Medicine Ltd Diabetes Manage. (2013) 3(2), 171–182 summary Ghrelin is an orexigenic hormone released from the stomach that stimulates the release of growth hormone and has been shown to inhibit the release of insulin. Evidence from rodent models of diabetes and perturbed ghrelin signaling suggest that ghrelin plays a role in regulating glucose ...

effect of oral presentation on development of l2 learners grammar

this experimental study has been conducted to test the effect of oral presentation on the development of l2 learners grammar. but this oral presentation is not merely a deductive instruction of grammatical points, in this presentation two hypotheses of krashen (input and low filter hypotheses), stevicks viewpoints on grammar explanation and correction and widdowsons opinion on limited use of l1...